Clinical Trial Manager (CTM) - US/Remote

Syneos Health® is a leading fully-integrated life sciences services organization built to accelerate customer success. We partner with innovators at every point across the drug development and commercialization continuum, helping them navigate complexity, anticipate change and accelerate progress.
 
Our Clinical Solutions team members act with a drug development mindset, applying their years of experience and deep expertise to truly understand customer needs and represent those in the solutions we shape.
 
Whether you join us in a Functional Service Provider partnership or a Full-Service environment, you’ll collaborate with passionate problem solvers, innovating as a team to help our customers achieve their goals. We are agile and driven to deliver – for one another, our customers, and, most importantly, for those in need.
 
Discover what your 25,000 future colleagues already know:
 
Why Syneos Health
• We are passionate about developing our people, through career development and progression; supportive and engaged line management; technical and therapeutic area training; peer recognition and total rewards program.
• We are committed to building an inclusive culture – where you can authentically be yourself. Central to this is our purpose – Driven to Deliver – which captures the passion of our colleagues to show up each day and shape solutions that have the ability to dramatically impact someone’s life. 
• We are continuously building the company we all want to work for and our customers want to work with. Why? Because we know that when we bring together smart colleagues from across the world, we can shape the future of healthcare, driving impact for customers and defining the pace of patient progress. 

Job Responsibilities

Lead Global Clinical Trials | Drive Innovation | Advance Patient Impact

At Syneos Health, we bring together clinical development and commercialization expertise to help our customers accelerate the delivery of life-changing therapies. By integrating clinical operations, medical affairs, and commercial insights, we create smarter, faster development pathways—always with patients at the center.

We’re expanding our Clinical Operations team and are seeking Clinical Trial Managers (CTMs) who are passionate about operational excellence, collaborative leadership, and delivering high-quality global clinical trials.

As a Clinical Trial Manager, you will serve as the operational leader for one or more clinical trials, owning execution from study start-up through closeout. You’ll work within a dynamic, matrixed environment—partnering closely with cross-functional teams, sponsors, and sites to ensure timely, compliant, and high-quality trial delivery.

This is an opportunity to lead complex studies, influence outcomes, and play a key role in advancing innovative therapies to patients worldwide.

• Lead end-to-end clinical trial execution, ensuring delivery against timelines, quality standards, and budget

• Provide operational oversight of site management and monitoring activities, including on-site and centralized monitoring

• Identify, assess, and proactively mitigate clinical and operational risks using a risk-based management approach (RACT)

• Serve as the primary escalation point for CRAs, investigative sites, and cross-functional stakeholders

• Partner closely with Study Start-Up, Data Management, Biostatistics, Safety, and Patient Recruitment teams to drive milestone achievement

• Leverage integrated systems and data (CTMS, EDC, ePRO, TMF, dashboards) to monitor performance, trends, and risk indicators

• Ensure ongoing inspection readiness and compliance with ICH-GCP, SOPs, and global regulatory requirements

• Lead study-specific training and foster alignment across the clinical trial team

• Review metrics and operational data to anticipate challenges and implement timely solutions

• Mentor and support CRAs, contributing to a culture of accountability, continuous improvement, and collaboration

Required

• Hands-on Clinical Research Associate (CRA) experience, including on-site monitoring (not remote-only)

• 2+ years of experience as a Clinical Trial Manager, preferably within a CRO environment

• Strong understanding of global clinical trial operations and site management

Preferred Strengths

• Demonstrated success leading cross-functional, global clinical teams

• Solid experience with risk-based monitoring and centralized oversight models

• Deep knowledge of ICH-GCP and international regulatory requirements

• Strong analytical, critical-thinking, and problem-solving capabilities

• Confident communicator with the ability to navigate complex stakeholder and sponsor environments

• Comfortable working in a global, matrixed organization

• Proficiency with clinical trial systems (CTMS, EDC, ePRO, TMF)

• Experience in oncology and/or ophthalmology is a strong asset

WHY SYNEOS HEALTH?

• Be part of a global, innovative organization with a strong and diverse pipeline of clinical programs

• Lead high-impact, complex trials across multiple therapeutic areas

• Work in a collaborative, inclusive environment where your expertise and perspective matter

• Gain exposure to a wide range of sponsors—from emerging biotech to top global pharmaceutical companies

• Access clear pathways for career growth, leadership development, and continuous learning

Salary Range $132,000 - $178,000 USD

At  Syneos Health, we believe in providing an environment and culture in which Our People can thrive, develop and advance. We reward and recognize our people by providing valuable benefits and a quality-of-life balance. The benefits for this position may include a company car or car allowance, Health benefits to include Medical, Dental and Vision, Company match 401k, eligibility to participate in Employee Stock Purchase Plan, Eligibility to earn commissions/bonus based on company and individual performance, and flexible paid time off (PTO) and sick time.  Because certain states and municipalities have regulated paid sick time requirements, eligibility for paid sick time may vary depending on where you work. Syneos complies with all applicable federal, state, and municipal paid sick time requirements.

Salary Range:

The base salary range represents the anticipated low and high of the Syneos Health range for this position. Actual salary will vary based on various factors such as the candidate’s qualifications, skills, competencies, and proficiency for the role.

Get to know Syneos Health

Over the past 5 years, we have worked with 94% of all Novel FDA Approved Drugs, 95% of EMA Authorized Products and over 200 Studies across 73,000 Sites and 675,000+ Trial patients.

No matter what your role is, you’ll take the initiative and challenge the status quo with us in a highly competitive and ever-changing environment. Learn more about Syneos Health.

http://www.syneoshealth.com

Additional Information

Tasks, duties, and responsibilities as listed in this job description are not exhaustive.  The Company, at its sole discretion and with no prior notice, may assign other tasks, duties, and job responsibilities. Equivalent experience, skills, and/or education will also be considered so qualifications of incumbents may differ from those listed in the Job Description.  The Company, at its sole discretion, will determine what constitutes as equivalent to the qualifications described above.   Further, nothing contained herein should be construed to create an employment contract.  Occasionally, required skills/experiences for jobs are expressed in brief terms.  Any language contained herein is intended to fully comply with all obligations imposed by the legislation of each country in which it operates, including the implementation of the EU Equality Directive, in relation to the recruitment and employment of its employees.  The Company is committed to compliance with the Americans with Disabilities Act, including the provision of reasonable accommodations, when appropriate, to assist employees or applicants to perform the essential functions of the job.