Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
Arrowhead Pharmaceuticals is seeking a high-performing and strategic Regional Sales Director (RSD) to lead District Managers and drive regional execution across our expanding cardiometabolic portfolio. This role is critical to launch excellence, sustained prescriber activation, and long-term regional growth as we bring innovative RNAi therapies—including Plozasiran—to patients with rare and high-need cardiovascular conditions.
The Regional Sales Director will serve as a key commercial leader responsible for translating national strategy into disciplined regional execution, building high-performing leadership teams, and ensuring consistent, compliant, and impactful customer engagement across priority territories.
This is a field-based position in the West Region.
Responsibilities
Regional Strategy & Business Leadership
- Translate national commercial strategy into comprehensive, actionable regional business plans aligned to launch and growth objectives.
- Own regional revenue targets, performance metrics, and forecast accuracy.
- Analyze prescribing trends, market dynamics, and territory insights to optimize resource deployment and execution.
- Conduct regular regional business reviews to assess performance, identify gaps, and implement corrective action plans.
- Ensure strong alignment between breadth execution (Sales Representatives) and depth strategy (Key Account Managers).
Leadership & Talent Development
- Recruit, develop, and retain high-performing District Managers.
- Provide structured coaching through field rides, performance reviews, and leadership development planning.
- Elevate leadership capability in coaching clinical acumen, access navigation, and disciplined territory management.
- Build and maintain a succession pipeline to support long-term organizational growth.
- Foster a culture of accountability, collaboration, and compliance across the region.
Execution Excellence & Launch Readiness
- Drive disciplined call planning and consistent execution across territories.
- Ensure alignment and pull-through across priority health systems and IDNs in partnership with KAM leadership.
- Monitor leading indicators such as adoption rates, speaker program execution, and engagement quality.
- Champion launch readiness initiatives and ensure sustained performance momentum post-launch.
Cross-Functional Enterprise Collaboration
- Partner closely with National Sales Director to ensure regional alignment with national objectives.
- Collaborate with Regional KAM Associate Directors to synchronize enterprise and prescriber-level strategies
- Coordinate with Market Access, Marketing, Medical Affairs, Health IT, and Commercial Operations to remove barriers and enhance adoption.
- Provide strategic regional insights regarding competitive activity, access challenges, and market trends.
Compliance & Operational Governance
- Ensure full adherence to company policies, promotional guidelines, and regulatory standards.
- Model compliant leadership behaviors and reinforce ethical conduct across the organization.
- Manage regional budgets responsibly, including promotional and operational expenditures.
Travel & Engagement
- Extensive regional travel required (~60%) including field coaching and customer engagement.
- Participation in national meetings, launch events, and strategic planning sessions.
Requirements
- 7+ years of pharmaceutical or biotech experience required.
- 3+ years of field leadership experience.
- Demonstrated success leading high-performing sales teams in specialty or rare disease environments.
- Launch experience or high-growth franchise leadership experience highly desirable.
- Cardiovascular or cardiometabolic therapeutic area experience preferred.
Skills & Competencies
- Proven ability to develop and coach leaders and sales teams to achieve superior performance.
- Strong business acumen with the ability to analyze complex data and translate insights into action.
- Executive presence and strong communication skills.
- Ability to navigate complex healthcare systems and support system-level alignment.
- High level of accountability and performance orientation.
- Strategic thinking combined with operational discipline.
- Ability to thrive in a dynamic, fast-paced, growth-oriented environment.
#LI-VR1 #LI-REMOTE
Arrowhead provides competitive salaries and an excellent benefit package.
All applicants must have authorization to work in the US for a company.
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